It is the first game to debut on the Nintendo DS and the Xbox 360. The Xbox 360 version features improved graphics, but retains gameplay similar to the other console versions. The edit mode has been stripped down for the Xbox 360 release, due to time restrictions.
The graphics engine on the PC does not utilise the next-gen 360 engine but will again be a direct conversion of the PlayStation 2 engine. A Bundesliga license was supposed to be a feature of the game but Konami were forced to remove the Bundesliga license, which means the Bundesliga is not present in PES6, not even as a series of unlicensed teams, with the exception of FC Bayern Munich who were fully licensed with the omission of their shirt sponsor T-Home.